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Record W2119861069 · doi:10.1016/j.carj.2014.12.002

Computed Tomography and the Secrets of Lung Nodules

2015· review· en· W2119861069 on OpenAlexaff
John R. Mayo, Stephen Lam

Bibliographic record

VenueCanadian Association of Radiologists Journal · 2015
Typereview
Languageen
FieldMedicine
TopicLung Cancer Diagnosis and Treatment
Canadian institutionsBC Cancer AgencyUniversity of British Columbia
Fundersnot available
KeywordsMedicineChest radiographPneumothoraxRadiologyLung cancerLungRadiographyPneumoniaNodule (geology)Solitary pulmonary noduleLung cancer screeningComputed tomographyInternal medicine

Abstract

fetched live from OpenAlex

Imaging is pivotal in chest disease diagnosis as the chest wall renders the heart and lungs inaccessible to physical examination and chest disease symptoms are very nonspecific (eg, cough, shortness of breath). Very early in the development of medical x-ray technology, it was recognized that the chest radiograph could provide essential diagnostic information (eg, pneumonia, lung masses, pneumothorax, cardiac failure). For this reason there was rapid uptake of chest radiography, and it continues to be highly relevant, over 100 years later. However, the chest radiograph has substantial limitations as it only provides a single, 2-dimensional view of the complex 3-dimensional structure of the chest. Even with the addition of the lateral view, detection of small lung nodules may substantially vary amongst expert radiologists. Thus, while lung masses greater than 30 mm in diameter are reliably identified, it has been shown that depending on location, lung nodules may be missed with a median diameter of 19 mm [1]. The strongest prognostic indicator of lung nodule malignant potential is size. Therefore, the detection of small lung cancers is strongly correlated with improved 5-year survival. In the hope of improving lung cancer survival, randomized clinical trials of screening chest radiography were performed in the 1970s. However, these trials failed to show a significant effect on lung cancer mortality [2]. Failure of these trials to impact mortality was believed by some to be secondary to poor imaging of small nodules using plain radiography. Poor imaging also limited our understanding of the link between

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.009
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.075
Threshold uncertainty score0.149

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.009
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.002
Science and technology studies0.0010.003
Scholarly communication0.0020.002
Open science0.0010.001
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0090.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.312
Teacher spread0.287 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2015
Admission routes1
Has abstractyes

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Same venueCanadian Association of Radiologists JournalSame topicLung Cancer Diagnosis and TreatmentFrench-language works237,207