A case of orthostatic hypotension induced by systemic amy- loidosis successfully treated with Bortezomib: infiltra- tion of amyloid proteins into various organs and change of targeted organs by therapy
Bibliographic record
Abstract
In some multiple myeloma cases, symptoms of amyloidosis are exhibited more prominently than symptoms of multiple myeloma. These cases are believed to have poorer prognosis compared to those in whom the major symptom is not amyloidosis. On the other hand, the prognosis of patients in whom amyloidosis is associated with peripheral neuropathy is poor, and suitable therapeutics has not been established. In this paper, we report a case of severe orthostatic hypotension as the major symptom associated with systemic amyloidosis. The patient was treated with bortezomib followed by autologous peripheral blood stem cell transplantation. This case was rare in that after relapse; amyloid protein was deposited in different organs, resulting in treatment resistance.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".