Frustrierte Lewis‐Paare: metallfreie Wasserstoffaktivierung und mehr
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- Meta-epidemiology (narrow), Research integrity, Insufficient payload (model declined to judge)
- Consensus categories
- Meta-epidemiology (narrow), Insufficient payload (model declined to judge)
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: Bench or experimentalConsensus signal: Bench or experimental
- Genre
- Candidate signal: EmpiricalConsensus signal: Empirical
- Teacher disagreement score
- 0.513
- Threshold uncertainty score
- 1.000
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.002 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.011 | 0.001 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.238 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
Abstract Die Kombination sterisch gehinderter Lewis‐Säuren und ‐Basen führt nicht zur üblichen Neutralisationsreaktion unter Bildung der “klassischen” Lewis‐Säure/Base‐Addukte. Stattdessen stehen die Lewis‐Acidität und ‐Basizität solcher “frustrierten Lewis‐Paare” (FLPs) gemeinsam für die Durchführung ungewöhnlicher Reaktionen zur Verfügung. Typische Beispiele für FLPs bestehen aus inter‐ und intramolekularen Kombinationen sperriger Phosphine und Amine mit stark elektrophilen RB(C 6 F 5 ) 2 ‐Komponenten. Viele frustrierte Lewis‐Paare sind in der Lage, Wasserstoff heterolytisch zu spalten. Die resultierenden H + /H − ‐Paare (z. B. stabilisiert in Form der entsprechenden Phosphonium‐Kation/Hydridoborat‐Anion‐Salze) fungieren als metallfreie Katalysatoren für die Hydrierung sperriger Imine, Enamine, Enolether usw. FLPs reagieren auch mit Alkenen, Carbonylverbindungen und einer Vielzahl anderer kleiner Moleküle, darunter auch Kohlendioxid, in vermutlich kooperativen Dreikomponentenreaktionen. Auf dieser Beobachtung lassen sich neue Synthesestrategien aufbauen.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Angewandte Chemie
- Topic
- Organoboron and organosilicon chemistry
- Field
- Chemistry
- Canadian institutions
- University of Toronto
- Funders
- not available
- Keywords
- ChemistryLewis acids and basesMedicinal chemistryFrustrated Lewis pairStereochemistryCatalysisOrganic chemistry
- Has abstract in OpenAlex
- yes