Ferrocene Conjugates Containing Diarginine and Aspartic Acid: Salt Bridge Interactions in Water
Bibliographic record
Abstract
Abstract The ferrocene peptide conjugates of diarginine (MeO‐Fc‐Arg‐Arg‐NH2) (1) and aspartic acid [Boc‐Fca‐Asp(OH)‐OH] (2) were found to form a stable 1:1 associate in aqueous solution. The molecular recognition was achieved through a combination of multipoint hydrogen bonding (H‐bonding) sites and a guanidinium‐carboxylate ion pair. The associate stoichiometry was confirmed by using ESI‐MS and NMR experiments; the NMR titration curve shows multiple equilibria with stepwise interconversion from 1:2 → 1:1 binding ratios, and the electrochemical behaviour of the ferrocenyl groups (Fc, Fca) confirm the formation of an ion pair. The CD spectra in the peptide region exhibit a characteristic absorption of a more ordered structure, while the ferrocene helical chirality remains intact. The solid‐state IR measurements exclude the involvement of the amide backbone in the interaction.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".