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Record W2126455391 · doi:10.1093/eurheartj/sup018

Heart rate and atherosclerosis

2009· article· en· W2126455391 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueEuropean Heart Journal Supplements · 2009
Typearticle
Languageen
FieldMedicine
TopicHeart rate and cardiovascular health
Canadian institutionsUniversité de MontréalMontreal Heart Institute
Fundersnot available
KeywordsMedicineIvabradineCardiologyEndothelial dysfunctionCoronary atherosclerosisInternal medicineEndotheliumPopulationHeart rateCoronary heart diseaseBlood pressure

Abstract

fetched live from OpenAlex

Heart rate (HR) is a potent predictor of major cardiovascular events in both the general population and the patients with various cardiovascular diseases. An increased HR has been shown to be associated with increased progression of coronary atherosclerosis in animal models and patients. A high HR has also been associated with a greatly increased risk of plaque rupture in patients with coronary atherosclerosis. Pure HR reduction has slowed atherosclerosis progression in experimental models. Endothelial function may be an important link between HR and atherosclerosis. An increased HR has been shown experimentally to cause endothelial dysfunction. The protective effect on the endothelium of long-term pure HR reduction with ivabradine that we have shown in a dyslipidaemic mouse model of endothelial dysfunction could provide an important mechanism for the potential vascular benefits of the If current inhibitor ivabradine. These results, in addition to those of the BEAUTIFUL study, constitute a strong rationale for further clinical investigation of the cardioprotective effects of pure HR reduction.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.241
Threshold uncertainty score0.560

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.048
GPT teacher head0.326
Teacher spread0.278 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it