Discoveries in Sulfenic Acid Anion Chemistry
Why this work is in the frame
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Bibliographic record
Abstract
Abstract Sulfenates, the conjugate bases of sulfenic acids are nucleophilic species that can be alkylated at sulfur to create sulfoxides. Sulfenates are generally not isolable, but must be generated and functionalized in solution. In this report, we summarize accomplishments toward the liberation of 1-alkenesulfenate anions and also the first general method for the release of alkane- and arenesulfenates. As prochiral entities, there is also potential for their stereoselective alkylation. As such, a protected cysteinesulfenate has been generated and alkylated at sulfur with dr's as high as 95:5. Also, when there is stereogenicity in the electrophile, diastereoselective alkylation of simple arenesulfenates occurs with dr's approaching and exceeding 9:1.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it