Synthesis and applications of water‐dispersible microspheres containing arborescent PAMAM surfaces
Bibliographic record
Abstract
Abstract This manuscript reports on a novel synthetic approach to engineer water‐dispersible microspheres with short poly(amidoamine) (PAMAM) chain grafted on their surface. These core‐shell polymeric microspheres have a large amount of amine groups on their surface obtained via “starburst” reactions. First, monodispersed poly (methyl methacrylate)‐co‐poly(glycidyl methacrylate) (P(MMA/GMA)) microspheres were prepared by surfactant‐free emulsion polymerization. Afterwards, Michael reaction and subsequent amidation reactions were carried out repetitively to synthesize arborescent PAMAM chains grafted on the surface of the P(MMA/GMA) microspheres. The resulting PAMAM‐grafted microspheres exhibit good dispersibility in aqueous environments. Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) demonstrate the successful grafting; furthermore, the crosslink degree of the P(MMA/GMA) microspheres as well as the PAMAM chain length affect the stability of the resulting core‐shell microspheres, as experimentally tested by heat treatment and acidic treatment. Easily, the PAMAM chains are protonated at low pH, and are thus able to effectively adsorb negatively‐charged magnetic nanoparticles. Bright photoluminescent (PL) water‐dispersible polymeric microspheres are fabricated readily via the reaction of the surface amine groups and traditional fluorescent molecules, namely fluorescein isothiocyanate (FITC). © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 2948–2959, 2008
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".