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Record W2126996939 · doi:10.1038/nsmb.2965

Structural basis for bifunctional peptide recognition at human δ-opioid receptor

2015· article· en· W2126996939 on OpenAlexafffund
Gustavo Fenalti, Nadia A. Zatsepin, Cecilia Betti, Patrick T. Giguere, Gye Won Han, Andrii Ishchenko, Weiwei Liu, Karel Guillemyn, Haitao Zhang, Daniel James, Dingjie Wang, Uwe Weierstall, John C. H. Spence, Sébastien Boutet, M. Messerschmidt, Garth J. Williams, Cornelius Gati, Oleksandr Yefanov, Thomas A. White, D. Oberthüer, Markus Metz, Chun Hong Yoon, Anton Barty, Henry N. Chapman, Shibom Basu, Jesse Coe, Chelsie E. Conrad, Raimund Fromme, Petra Fromme, Dirk Tourwé, Peter W. Schiller, Bryan L. Roth, Steven Ballet, Vsevolod Katritch, Raymond C. Stevens, Vadim Cherezov

Bibliographic record

VenueNature Structural & Molecular Biology · 2015
Typearticle
Languageen
FieldNeuroscience
TopicNeuropeptides and Animal Physiology
Canadian institutionsUniversité de MontréalMontreal Clinical Research Institute
FundersBasic Energy SciencesNational Institute on Drug AbuseNational Institute of Mental HealthNational Science FoundationCanadian Institutes of Health ResearchVlaamse regeringFonds Wetenschappelijk OnderzoekNational Institute of General Medical SciencesBundesministerium für Bildung und ForschungDeutsche ForschungsgemeinschaftU.S. Department of EnergyNational Cancer InstituteNational Institutes of Health
KeywordsTetrapeptideBifunctionalPeptideNociceptin receptorChemistryAgonistOpioid peptideOpioid receptorReceptorPharmacologyAntagonistOpioidStereochemistryBiochemistryMedicine

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.037
GPT teacher head0.320
Teacher spread0.284 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations179
Published2015
Admission routes2
Has abstractyes

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