Reactivation of Chagas disease with central nervous system involvement: peripheral blood smear evidence
Bibliographic record
Abstract
In September 2008, a 35-year-old Argentinean man was admitted to hospital with fever and disorientation. A contrast computed tomography scan and magnetic resonance imaging showed two intracranial abscesses. The patient was treated initially with ceftriaxone, but over the course of two weeks of treatment his condition gradually worsened. Approximately two weeks after starting treatment, a Giemsa-stained blood smear was performed in our department, and four Trypanosoma cruzi-like parasites were observed with a ×100 oil-immersion objective lens (Figure 1). Subsequently, to establish the confirmatory diagnosis of T. cruzi infection, two immunoserological tests (complement fixation test, CFT) were carried out in our patient, and the diagnosis was positive. One day after our observation, HIV-1 (CDC stage C3) infection was confirmed, and a stereotactic brain biopsy of the frontal abscess showed the presence of the parasites in the central nervous system (CNS). In Latin America, one of the most important endemic protozoonoses is Chagas disease, caused by the protozoan parasite T. cruzi. Economic hardship, political problems, or both, have spurred migration from Chagas endemic countries to developed countries. The main destinations of this immigration are Australia, Canada, Spain, and the USA. Recent reports in the literature have provided evidence for reactivation of some protozoonoses in patients infected with HIV. A great number of chagasic patients are now migrating from rural zones to the large cities where the possibility of acquiring HIV is greater. Cases of Chagas disease–AIDS co-infection with CNS involvement have been reported in the literature, although cerebral lesions have only rarely been observed in chronic chagasic immunocompetent patients. To date, around 50 cases of CNS involvement in the association of Chagas disease–AIDS are known and have been reported at scientific meetings.1Cordova E. Boschi A. Ambrosioni J. Cudos C. Corti M. Reactivation of Chagas disease with central nervous system involvement in HIV-infected patients in Argentina, 1992–2007.Int J Infect Dis. 2008; 12: 587-592Abstract Full Text Full Text PDF PubMed Scopus (113) Google Scholar, 2Chicharro C. Alvar J. Lower trypanosomatids in HIV/AIDS patients.Ann Trop Med Parasitol. 2003; 97: 75-78Crossref PubMed Scopus (59) Google Scholar, 3de Oliveira Santos E. dos Reis Canela J. Gomes Monção H.C. Guedes Roque M.J. Reactivation of Chagas’ disease leading to the diagnosis of acquired immunodeficiency syndrome.Braz J Infect Dis. 2002; 6: 317-321Crossref PubMed Google Scholar Our case shows a very unusual clinical picture of an HIV–T. cruzi co-infection with CNS involvement. Conflict of interest: No conflict of interest to declare.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".