Evaluating nuchal translucency scans performed for trisomy screening in a district general hospital between July 1998 and January 2004
Bibliographic record
Abstract
In October 2003, The National Institute for Clinical Excellence recommended screening tests for Down's syndrome (DS) to come into effect from April 2007. These tests were recommended based on studies performed in research centres. Some of the recommended tests have a fetal nuchal translucency scan component. In this retrospective study at the Basildon and Thurrock University Hospital we have evaluated nuchal translucency (NT) scans performed between July 1998 and January 2004 on 18,965 fetuses with a view to comparing our findings with research centres. In spite of our high standards, our detection rate for DS was 72.0% (95% CI 56.0-83.8%) for a 5% false positive rate. This was much lower than the 85% reported from the seminal paper in 1994. We believe that the advice given to women should be based on data from working programmes and not research units.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.008 |
| Meta-epidemiology (narrow) | 0.000 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.003 | 0.003 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".