Design and implementation of MEMS based microneedles for biomedical applications
Bibliographic record
Abstract
This paper addresses the practical design and implementation MEMS (microelectro-mechanical system) based in-plane silicon microneedles for transdermal drug delivery and/or blood sampling for biomedical and biotechnology applications. The characteristics of in-plane microneedles are far more reliable than out-of-plane microneedles for transdermal drug delivery and blood sampling. In order to obtain the sample of blood from the subcutaneous fat layer, which occurs at a distance of 2000 to 4000 /spl mu/m below the skin surface, the length of our MEMS based in-plane microneedle have been set at 3000 /spl mu/m. This microneedle length is impractical for out-of-plane microneedles. Drug delivery and blood samplings place requirement in terms of minimal needle dimensions and force withstanding capabilities, which are inversely related to each other. The strength of the microneedles has been examined analytically and modeled using finite element modeling tools. Through performance analysis it is shown that the proposed design is a significant improvement over existing microneedles.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".