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ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

2005· article· en· 707 citations· W2128327076 on OpenAlex· 10.1038/sj.emboj.7600777

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
ObservationalBench or experimental
Classifier consensus
Bench or experimental
Teacher imitation scores

Codex

Bench or experimental0.297
Observational0.030
Other design0.008
Not applicable0.003
Theoretical or conceptual0.003
Randomized trial0.000
Simulation or modelling0.000
Case report0.000
Scholarly communication0.000
Open science0.000
Research integrity0.000
Non-randomized trial0.000
Qualitative0.000
Metaresearch0.000
Science and technology studies0.000
Systematic review0.000
Meta-analysis0.000
Meta-epidemiology (narrow)0.000
Meta-epidemiology (broad)0.000
Bibliometrics0.000

Gemma

Bench or experimental0.382
Observational0.021
Simulation or modelling0.006
Not applicable0.003
Theoretical or conceptual0.002
Case report0.001
Non-randomized trial0.000
Research integrity0.000
Randomized trial0.000
Qualitative0.000
Open science0.000
Metaresearch0.000
Science and technology studies0.000
Scholarly communication0.000
Systematic review0.000
Meta-analysis0.000
Meta-epidemiology (narrow)0.000
Meta-epidemiology (broad)0.000
Bibliometrics0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.012
GPT teacher head0.231
Teacher spread
0.218 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

Tumor cell adaptation to hypoxic stress is an important determinant of malignant progression. While much emphasis has been placed on the role of HIF-1 in this context, the role of additional mechanisms has not been adequately explored. Here we demonstrate that cells cultured under hypoxic/anoxic conditions and transformed cells in hypoxic areas of tumors activate a translational control program known as the integrated stress response (ISR), which adapts cells to endoplasmic reticulum (ER) stress…

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