A new altruist on the block: effects of adrenomedullin after myocardial infarction
Bibliographic record
Abstract
See article by Nakamura et al. [15] (pages 373–380) in this issue. The first few weeks after myocardial infarction (MI) are critical to the evolution of compensated to decompensated heart failure; it is generally agreed that the rapidity of cardiac dysfunction in these hearts depends on the magnitude of the initial insult [1]. From a clinical standpoint, it stands to reason that any process that may interrupt or abrogate secondary ventricular remodeling with attendant loss of normal chamber geometry may also attenuate the rate of functional decline of the remnant heart. The hallmark of maladaptive change in the post-MI heart is increased myocyte size; this change is associated with decreased intrinsic cardiac performance [2]. Alternatively, the premise that post-MI heart failure stems from not only abnormalities in cardiac myocytes but may also be linked to unusual behaviour of non-myocytes, i.e., myofibroblasts, seems to be borne out by data from recent studies [3,4]. Recent attention has focused on the acute pattern of changes that transpire in the healing infarct scar and remnant myocardium, loosely connected by the general hypothesis that events in early post-MI healing may serve to set the pace for the onset of cardiac decompensation. In this context, basic cardiovascular research specializing in a subset of novel factors that may have anti-growth and anti-proliferative properties for cardiac cells is burgeoning. In this scenario, multiple factors with opposing functions (operating via autocrine or paracrine modes) may participate in the acute phase of wound healing and continue to exert their effects in the chronic post-MI heart. As (i) the prognosis for patients who manage to survive the acute phase of a large MI and who yet go on to develop maladaptive hypertrophy remains dismal, and (ii) the list of new agents for treatment of this disease has not grown appreciably in the last 10 years, an understanding of naturally occurring factors that tend to oppose cardiac remodeling per se is well worth further investigation. An improved understanding of endogenous adaptive changes of the myocardium may provide a basis for exploitation in delaying the onset of maladaptive hypertrophy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.010 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.022 | 0.022 |
| Insufficient payload (model declined to judge) | 0.003 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".