Functions of lipoprotein receptors in neurons

The LDL receptor (LDLR) family is comprised of several multifunctional cell surface proteins that bind and endocytose ligands with diverse biological functions. One ligand common to all LDLR family members is apolipoprotein E (apoE), a lipid transport protein that also plays a central role in the pathogenesis of neurodegeneration in Alzheimer's disease.This review discusses the role of apoE and its receptors in the central nervous system and, in particular, the signaling mechanisms by which two members of the LDLR gene family, apoE receptor-2 and VLDL receptor, control brain development, normal and in the The LDL receptor (LDLR) family is comprised of several multifunctional cell surface proteins that bind and endocytose ligands with diverse biological functions. One ligand common to all LDLR family members is apolipoprotein E (apoE), a lipid transport protein that also plays a central role in the pathogenesis of neurodegeneration in Alzheimer's review discusses the role of apoE and its receptors in the central nervous system and, in particular, the signaling mechanisms by which two members of the LDLR gene family, apoE receptor-2 and VLDL receptor, control brain development, normal and in the The of the LDL receptor (LDLR) family a of multifunctional cell surface proteins that bind and endocytose ligands with diverse biological functions. signaling to members of and gene family in The LDL receptor gene in the LDLR family members in which the and in a that is to that of in a that of and the One ligand that to of in the of all LDLR gene family members is apolipoprotein E apoE its the the receptors to which that a that of a receptor also that the of the LDLR gene family the of the the transport of and a system in in the receptor in to the members 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