The Human Homologue of Flamingo, EGFL2, Encodes a Brain-Expressed Large Cadherin-Like Protein with Epidermal Growth Factor-Like Domains, and Maps to Chromosome 1p13.3-p21.1
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Bibliographic record
Abstract
The epidermal growth factor (EGF)-like domain, spanning approximately 50 amino acids and with three disulphide bonds, is the defining characteristic of a superfamily of genes of very diverse functions. This gene family includes proteins involved in cell adhesion and receptor-ligand interactions, and has such diverse members as notch, fibrillin and the low-density lipoprotein (LDL) receptor. EGF-like proteins are often involved in cell cycle control and cell proliferation and are thus potentially useful candidates for drug targeting in tumours. EGF-like proteins are frequently more than 1000 amino acids in length, with multiple copies of the EGF-like domain, and with additional domains for specific protein-protein interactions. A partial cDNA clone, termed KIAA0279 (D87469) was identified that encodes for a gene, epidermal growth factor-like 2 (EGFL2; MIM# 604265), containing EGF-like repeats and cadherin repeat motifs. EGFL2 shows a high degree of homology (95%) with rat MEGF2 {rMEGF2 AB011528), and to the mouse gene, Flamingo 1 (mFmil; AB028499), and was actually used in the cloning of mFmil. Flamingo (Fmi) is a seven-pass transmembrane protein of the cadherin superfamily that was recently cloned from Drosophila melanogaster and from mouse, and is thought to regulate planar cell polarity. Fmi, in addition to possessing a multiple cadherin repeat region in the ectodomain, also contains a cysteine-rich region similar to the EGF-like domain. We have cloned the 5'end of a gene that overlaps with the EGFL2 cDNA clone KIAA0279. Together, the combined cDNAs comprise the full length EGFL2 gene which encodes a putative protein that is 2923 amino acids in length and that has 94% amino acid identity with mFmil. EGFL2 is expressed strongly in brain tissue, and maps to chromosome Ipl3.321.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it