Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women
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- Teacher spread
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Abstract
While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in the Women's Genome Health Study, we find that three SNPs at the ICAM1 (19p13.2) locus (rs1799969, rs5498 and rs281437) are non-redundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level (P<5x10(-8)), thus extending prior results from linkage and candidate gene studies. We also find that a single SNP (rs507666, P = 5.1x10(-29)) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes.
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The record
- Venue
- PLoS Genetics
- Topic
- Blood groups and transfusion
- Field
- Medicine
- Canadian institutions
- —
- Funders
- AmgenNational Cancer InstituteFonds de Recherche du Québec - SantéDoris Duke Charitable Foundation
- Keywords
- ABO blood group systemGenome-wide association studyLocus (genetics)BiologySingle-nucleotide polymorphismSNPGenetic associationGeneticsGeneGenotype
- Has abstract in OpenAlex
- yes