PHOTO-INDUCED CHARGE FLOW THROUGH CANONICAL DNA/RNA AND NON-CANONICAL DNA CONTAINING TRINUCLEOTIDE REPEATS
Bibliographic record
Abstract
The charge flow technique is used to study structure of nucleic acids. DNA-DNA duplexes and DNA-RNA heteroduplexes have been studied using charge transfer, yet little is known about RNA-RNA duplex conductivity. Both piperidine and aniline treatment on DNA-DNA duplexes with guanine-rich termini generated a large oxidative end-effect. Both DNA-DNA and RNA-RNA duplexes demonstrated similar findings. Sensitivity of the end-effect towards mismatches suggests its utility as sensitive reporter of mismatches. Various diseases are associated with polymorphic DNA trinucleotide repeats (TNR). Disease associated TNRs (CAG, CGG, CCG, CTG) can form alternative DNA structures in vitro with two Watson-Crick base pairs sandwiching single mismatches. Mismatches interrupt base stacking and hence are known to affect duplex conductivity. Charge flow through duplexes carrying TNRs did not show any statistically significant difference in damage. The increase in damage from 10 oC to 21 oC, was not statistically significant. Our approach could not be applied to TNRs.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".