Activated Stat5 levels do not increase with cell density in contrast to activated Stat3 levels in breast epithelial cell culture
Bibliographic record
Abstract
Background The Signal Transducer and Activator of Transcription-3 (Stat3) is activated by cytokine receptors such as the IL6 receptor (IL6R) family, as well as Src and Abl. In cancer, Stat3 can become constitutively active, regulate genes involved in survival, proliferation and invasion, and has been associated with poor survival in breast cancer patients. Our group recently discovered a novel pathway of Stat3 activation triggered by engagement of cadherins, cell to cell adhesion molecules, which induce high levels of Rac and transcriptional activation of IL6. Another Stat family member, Stat5, is known to promote breast differentiation and lactation in response to lactogenic hormones, and its activation correlates with a more differentiated breast tumour phenotype.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".