Celecoxib was similar to naproxen for rheumatoid arthritis with fewer endoscopic ulcers
Bibliographic record
Abstract
(1999) JAMA 282, 1921. Simon LS, Weaver AL, Graham DY, et al. . Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis. A randomized controlled trial. . Nov 24; . : . –8 . [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] QUESTION: In patients with rheumatoid arthritis (RA), is celecoxib as efficacious (in anti-inflammatory and analgesic effects) and safe (in avoiding endoscopic upper gastrointestinal [GI] ulcers) as naproxen? Randomised (allocation concealed*), blinded (patients, clinicians, and outcome assessors),* placebo controlled, 12 week trial. 79 US and Canadian clinical sites. 1149 patients (mean age 54 y, 73% women) who had RA (American College of Rheumatology criteria) for >3 months. Inclusion criteria were age ≥18 years and receipt of stable medications; oral steroids and disease modifying antirheumatic drugs were allowed. Exclusion criteria were active GI tract, renal, hepatic, or coagulation disorders; history of cancer or gastric or duodenal surgery; or recent or current oesophageal or gastroduodenal ulcers or ≥10 erosions. 60% of patients completed the study; follow up was >99%. Symptomatic RA was confirmed after non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics were stopped for 2 to 7 days. Patients were then allocated to celecoxib, 100 mg twice/d (n=240), 200 mg twice/day (n=235), or 400 mg twice/day (n=218); naproxen, 500 mg twice/day (n=225); or placebo (n=231). NSAIDs, injectable corticosteroids, … [1]: {openurl}?query=rft.jtitle%253DJAMA%26rft.stitle%253DJAMA%26rft.issn%253D0002-9955%26rft.aulast%253DSimon%26rft.auinit1%253DL.%2BS.%26rft.volume%253D282%26rft.issue%253D20%26rft.spage%253D1921%26rft.epage%253D1928%26rft.atitle%253DAnti-inflammatory%2Band%2BUpper%2BGastrointestinal%2BEffects%2Bof%2BCelecoxib%2Bin%2BRheumatoid%2BArthritis%253A%2BA%2BRandomized%2BControlled%2BTrial%26rft_id%253Dinfo%253Adoi%252F10.1001%252Fjama.282.20.1921%26rft_id%253Dinfo%253Apmid%252F10580457%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1001/jama.282.20.1921&link_type=DOI [3]: /lookup/external-ref?access_num=10580457&link_type=MED&atom=%2Febmed%2F5%2F3%2F75.atom [4]: /lookup/external-ref?access_num=000083763400026&link_type=ISI
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Direct model labels (unvalidated)
Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.
| Model arm | Categories | Study design | Confidence |
|---|---|---|---|
| gemma | no category Domain: not available · Genre: Empirical About the Canadian research system: no · About a Canadian topic: no | Randomized trial | medium |
| gpt | no category Domain: not available · Genre: Empirical About the Canadian research system: no · About a Canadian topic: no | Randomized trial | high |
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedLabeled directly by 2 models reading the full record.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".