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Record W2131025913 · doi:10.1016/j.bbmt.2013.12.008

HLA-Mismatch Is Associated with Worse Outcomes after Myeloablative Conditioning and Unrelated Donor Hematopoietic Cell Transplantation: A Cibmtr Analysis

2014· article· en· W2131025913 on OpenAlexaff
Joseph Pidala, Stephanie J. Lee, Stephen R. Spellman, Hailin Wang, Kwang Woo Ahn, Mahmoud Aljurf, Medhat Askar, Jason Dehn, Marcelo Fernández-Viña, Aloïs Gratwohl, Vikas Gupta, Rabi Hanna, Carolyn Katovich Hurley, Yoshihiro Inamoto, Adetola A. Kassim, Taiga Nishihori, Machteld Oudshoorn, Effie W. Petersdorf, Vinod K. Prasad, Wael Saber, Kirk R. Schultz, William A. Wood, Jan Storek, Ann E. Woolfrey, Claudio Anasetti

Bibliographic record

VenueBiology of Blood and Marrow Transplantation · 2014
Typearticle
Languageen
FieldMedicine
TopicHematopoietic Stem Cell Transplantation
Canadian institutionsBritish Columbia Children's HospitalUniversity of TorontoFoothills Medical CentrePrincess Margaret Cancer Centre
Fundersnot available
KeywordsMedicineInternal medicineHuman leukocyte antigenTransplantationOncologyHematopoietic stem cell transplantationPopulationGraft-versus-host diseaseGastroenterologyImmunologyAntigen

Abstract

fetched live from OpenAlex

Previous studies have demonstrated the adverse impact of HLA mismatch on the outcome of myeloablative conditioning and unrelated donor allogeneic hematopoietic cell transplantation (HCT). These have had limited power in certain sub-groups, and do not reflect changes in HCT utilization and technology.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.012

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0040.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.228
Teacher spread0.221 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2014
Admission routes1
Has abstractyes

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