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Record W2131328125 · doi:10.1038/ng.838

Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2

2011· article· en· W2131328125 on OpenAlex
Fred A. Wright, Lisa J. Strug, Vishal Doshi, Clayton W. Commander, Scott M. Blackman, Lei Sun, Yves Berthiaume, David J. Cutler, Andreea L. Cojocaru, Joseph M. Collaco, Mary Corey, Ruslan Dorfman, Katrina A.B. Goddard, Deanna Green, Jack W. Kent, Ethan M. Lange, Seunggeun Lee, Weili Li, Jingchun Luo, Gregory M. Mayhew, Kathleen Naughton, Rhonda G. Pace, Peter D. Paré, Johanna M. Rommens, Andrew J. Sandford, Jaclyn R. Stonebraker, Wei Sun, Chelsea Taylor, Lori L. Vanscoy, Fei Zou, John Blangero, Julian Zielenski, Wanda K. O’Neal, Mitchell L. Drumm, Peter R. Durie, Michael R. Knowles, Garry R. Cutting

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueNature Genetics · 2011
Typearticle
Languageen
FieldMedicine
TopicCystic Fibrosis Research Advances
Canadian institutionsCentre Hospitalier de l’Université de MontréalInstitute for Clinical Evaluative SciencesUniversity of TorontoSickKids FoundationUniversity of British ColumbiaHospital for Sick ChildrenPublic Health Ontario
FundersNational Human Genome Research InstituteNational Institute of Mental HealthNational Institute of Diabetes and Digestive and Kidney DiseasesNational Heart, Lung, and Blood InstituteCanadian Institutes of Health Research
KeywordsGenome-wide association studyBiologyQuantitative trait locusCystic fibrosisLocus (genetics)GeneticsGenetic associationOdds ratioGenetic linkageInternal medicineGenotypeMedicineSingle-nucleotide polymorphismGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.020
Threshold uncertainty score0.568

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.287
Teacher spread0.276 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it