A PINOID-Dependent Binary Switch in Apical-Basal PIN Polar Targeting Directs Auxin Efflux
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Abstract
Polar transport-dependent local accumulation of auxin provides positional cues for multiple plant patterning processes. This directional auxin flow depends on the polar subcellular localization of the PIN auxin efflux regulators. Overexpression of the PINOID protein kinase induces a basal-to-apical shift in PIN localization, resulting in the loss of auxin gradients and strong defects in embryo and seedling roots. Conversely, pid loss of function induces an apical-to-basal shift in PIN1 polar targeting at the inflorescence apex, accompanied by defective organogenesis. Our results show that a PINOID-dependent binary switch controls PIN polarity and mediates changes in auxin flow to create local gradients for patterning processes.
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The record
- Venue
- Science
- Topic
- Plant Molecular Biology Research
- Field
- Agricultural and Biological Sciences
- Canadian institutions
- —
- Funders
- Natural Sciences and Engineering Research Council of CanadaJames S. McDonnell FoundationSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungNational Science Foundation
- Keywords
- AuxinPolar auxin transportCell biologyBiologyPolarity (international relations)Apex (geometry)Basal (medicine)BiophysicsMutantArabidopsisAnatomyBiochemistryCell
- Has abstract in OpenAlex
- yes