<i>MYO9B</i> polymorphisms in patients with inflammatory bowel disease
Bibliographic record
Abstract
An abnormal function of the intestinal barrier has been found not only in patients with inflammatory bowel disease (IBD) but even in their healthy relatives, suggesting that this condition may precede disease onset by years.1 A genetic alteration in the intestinal permeability has also been proposed to exist in patients with coeliac disease. In support of this proposal, polymorphisms in the MYO9B gene (the gene for myosin IXb involved in cytoskeleton remodelling) were found to be associated with increased susceptibility to coeliac disease.2 The MYO9B gene has recently been investigated in relation to IBD and produced discordant results. No association was observed in a Norwegian population,3 but shortly afterwards an international collaboration group performed a statistically powerful study on samples collected from the UK, Netherlands, Canada and Italy in which MYO9B was found to be associated with IBD, and with ulcerative colitis and Crohn’s disease considered separately in some populations.4 In that study, a stronger effect was seen …
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.004 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".