The Genetic Landscape of a Cell
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- Teacher spread
- 0.200 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles for approximately 75% of all genes in the budding yeast, Saccharomyces cerevisiae. A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function. The global network identifies functional cross-connections between all bioprocesses, mapping a cellular wiring diagram of pleiotropy. Genetic interaction degree correlated with a number of different gene attributes, which may be informative about genetic network hubs in other organisms. We also demonstrate that extensive and unbiased mapping of the genetic landscape provides a key for interpretation of chemical-genetic interactions and drug target identification.
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The record
- Venue
- Science
- Topic
- Bioinformatics and Genomic Networks
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- McGill UniversityLunenfeld-Tanenbaum Research InstituteMount Sinai HospitalYork UniversityUniversity of Toronto
- Funders
- National Human Genome Research InstituteCanadian Institutes of Health ResearchWellcome Trust
- Keywords
- BiologyPleiotropyGeneComputational biologyGeneticsSaccharomyces cerevisiaeGenomeGene mappingGene interactionGene regulatory networkBiological networkEvolutionary biologyPhenotypeChromosomeGene expression
- Has abstract in OpenAlex
- yes