Effect of Suprachiasmatic Nucleus Lesion on Period2 and C-fos Expression in Habenular Nucleus
Bibliographic record
Abstract
The habenular nucleus (Hb) located in the epithalamus is an important connection between the limbic forebrain and midbrain pathway and it regulates physiological activities including reproduction, sleep-wake, body temperature. Hb is anatomically close to the suprachiasmatic nucleus (SCN), the pacemaker of circadian rhythms in mammals. In vivo data showed circadian oscillation of Period2 (Per2) expression in Hb. However, it remains unknown whether the circadian oscillation of Per2 expression is regulated by SCN. We used semi-quantity RT-PCR methods to examine the relative expression of Per2 and c-fos mRNA in the Hb at 13:00 and 1:00 in the LD (light-dark) cycle either SCN was intact or destroyed. The expression of Per2 and c-fos mRNA in the Hb was higher at 13:00 than at 1:00. However, damaging the SCN abolished the difference of Per2 and c-fos mRNA expression at the two time ponits in the Hb, suggesting circadian oscillation of Per2 and c-fos gene in the Hb may be regulated by SCN under in vivo condition.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".