Water‐Soluble Maleimide‐Modified Gold Nanoparticles (AuNPs) as a Platform for Cycloaddition Reactions
Bibliographic record
Abstract
Abstract Maleimide‐terminated triethylene glycol thiolate monolayer‐protected gold nanoparticles (Mal‐EG4‐AuNPs) with a core size of 2.5 ± 0.7 nm were prepared. Mal‐EG4‐AuNPs were modified in high yields via interfacial 1,3‐dipolar cycloaddition and Diels–Alder reactions with a variety of nitrones and dienes, respectively. The resulting cycloadduct‐modified AuNPs were characterized using 1H NMR spectroscopy and were verified by comparison of the spectra to those of the products of the model reactions with the same nitrones and dienes. TEM analysis showed that the reaction conditions did not affect the shape or size of the gold core, suggesting that this is an efficient methodology to modify small water soluble AuNPs under ambient pressure and biological temperature with high yields and a reasonable reaction time.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".