The Yeast Nuclear Pore Complex
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- Teacher spread
- 0.205 · how far apart the two teachers sit on this one work
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Abstract
An understanding of how the nuclear pore complex (NPC) mediates nucleocytoplasmic exchange requires a comprehensive inventory of the molecular components of the NPC and a knowledge of how each component contributes to the overall structure of this large molecular translocation machine. Therefore, we have taken a comprehensive approach to classify all components of the yeast NPC (nucleoporins). This involved identifying all the proteins present in a highly enriched NPC fraction, determining which of these proteins were nucleoporins, and localizing each nucleoporin within the NPC. Using these data, we present a map of the molecular architecture of the yeast NPC and provide evidence for a Brownian affinity gating mechanism for nucleocytoplasmic transport.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- The Journal of Cell Biology
- Topic
- Nuclear Structure and Function
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- University of Alberta
- Funders
- National Center for Research Resources
- Keywords
- NucleoporinNuclear poreNuclear transportYeastComponent (thermodynamics)Cell biologyComputational biologyBiologyChemistryCytoplasmCell nucleusGeneticsPhysics
- Has abstract in OpenAlex
- yes