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Record W2133498037 · doi:10.1039/b906884h

Carbene-anchored/pendent-imidazolium species as precursors to di-N-heterocyclic carbene-bridged mixed-metal complexes

2009· article· en· W2133498037 on OpenAlexaff
Matthew T. Zamora, Michael J. Ferguson, Robert McDonald, Martín Cowie

Bibliographic record

VenueDalton Transactions · 2009
Typearticle
Languageen
FieldChemistry
TopicN-Heterocyclic Carbenes in Organic and Inorganic Chemistry
Canadian institutionsUniversity of Alberta
Fundersnot available
KeywordsCarbeneChemistryDeprotonationImidazoleMedicinal chemistryMoietyDiphosphinesMethyleneEthylenePalladiumStereochemistryCatalysisOrganic chemistry

Abstract

fetched live from OpenAlex

Reaction of a series of linked diimidazolium dibromide salts with one-half equivalent of [Rh(mu-OAc)(COD)](2) under reflux conditions generates a series of carbene-anchored/pendent-imidazolium complexes, [RhBr(COD)((R)C(H)-eta(1)-C(eth))][Br] ((Me)C(H)-eta(1)-C(eth) = ethylene[(N-methyl)imidazolium][(N-methyl)imidazole-2-ylidene] and (tBu)C(H)-eta(1)-C(eth) = ethylene[(N-tert-butyl)imidazolium][(N-tert-butyl)imidazole-2-ylidene]) via deprotonation of one end of the diimidazolium salt and coordination of the resulting carbene to Rh. Reaction of these complexes with carbon monoxide or the appropriate diphosphine yields either [RhBr(CO)(2)((R)C(H)-eta(1)-C(eth))][Br] (R = Me, (t)Bu) or [RhBr(P( intersection)P)((Me)C(H)-eta(1)-C(eth))][Br] (P( intersection)P = Ph(2)PCH(2)PPh(2), Ph(2)PCH(2)CH(2)PPh(2), Et(2)PCH(2)PEt(2)), respectively. The resulting diphosphine complexes readily decompose in solution. A series of palladium complexes [PdI(3-n)(PR(3))(n)(L)][I](n) (n = 1,2) and [PdI(P( intersection)P)(L)][I](2) (L = (tBu)C(H)-eta(1)-C(meth), (tBu)C(H)-eta(1)-C(eth); (tBu)C(H)-eta(1)-C(meth) = methylene[(N-tert-butyl)imidazolium][(N-tert-butyl)imidazole-2-ylidene]), containing the linked NHC-imidazolium moiety, have also been prepared by reacting the triiodo complexes, [PdI(3)((tBu)C(H)-eta(1)-C(meth))] and [PdI(3)((tBu)C(H)-eta(1)-C(eth))] with several mono- and diphosphines. Attempts to generate mixed Rh/Pd complexes using Pd(OAc)(2) to deprotonate the pendent arm of several of the above carbene-anchored/pendent-imidazolium complexes of Rh have proven unsuccessful. However, a targeted di-NHC-bridged heterobimetallic complex [PdI(2)(PEt(3))(mu-(tBu)CC(meth))RhI(COD)] ((tBu) CC(meth) = 1,1'-methylene-3,3'-di-tert-butyldiimidazol-2,2'-diylidene) can be generated by deprotonation of the imidazolium group in [PdI(2)(PEt(3))((tBu)C(H)-eta(1)-C(meth))][I] using half an equivalent of [Rh(mu-OAc)(COD)](2). The X-ray structure determination of this Pd/Rh complex confirms the dicarbene-bridged formulation and shows a metal-metal separation of approximately 6.2 A. Reaction of this Rh/Pd complex with CO yields the corresponding dicarbonyl product [PdI(2)(PEt(3))(mu-(tBu)CC(meth))RhI(CO)(2)] via replacement of the COD ligand. The related dicarbene-bridged Ir/Rh complex [IrBr(COD)(mu-(tBu)CC(meth))RhBr(COD)] can be generated by reaction of [IrBr(COD)((tBu)C(H)-eta(1)-C(meth) )][Br] with [Rh(mu-OAc)(COD)](2), while the Pd/Ir complexes [PdI(2)(PR(3))(mu-(tBu)CC(meth))IrI(COD)] (PR(3) = PPh(3), PMe(2)Ph) can be generated by reaction of the monometallic [PdI(2)(PR(3))((tBu)C(H)-eta(1)-C(meth))][I] species with K[N(SiMe(3))(2)] in the presence of [Ir(mu-Cl)(COD)](2). The carbonyl analogues, [PdI(2)(PR(3))(mu-(tBu)CC(meth))IrI(CO)(2)], can be generated via a gentle purge of CO gas. These di-NHC-bridged heterobimetallic species represent some of the first examples of this class and are the first involving palladium.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.046
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0100.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.247
Teacher spread0.235 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations46
Published2009
Admission routes1
Has abstractyes

Explore more

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