Evolution of Complementary Peptide Systems
Bibliographic record
Abstract
In chordates, the corticotropin-releasing factor (CRF) family of peptides consists of four paralogous lineages that include CRF, urocortin/urotensin-I, urocortin 2, and urocortin 3. Related to the CRF peptide family is the diuretic hormone family found in insects. This family consists of a number of paralogous lineages within the Insecta. The teneurin C-terminal-associated peptides (TCAP) are a recently described family of peptides with evolutionary origins around the same time as the CRF family. This family consists of four independent lineages in chordates that are orthologous to peptides in the Insecta. Like CRF, the peptides are 40 or 41 amino acids in length and share about 20% sequence identity to the CRF family members. Each of the four TCAP peptides is encoded by an exon that is closely associated with the teneurin gene. Recent studies indicate that TCAP can block CRF-mediated c-fos expression in the brain and modulate CRF-mediated behaviors. Thus, the TCAP family may act, in part, to modulate the physiological actions of the CRF family.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.006 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".