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Record W2134631886 · doi:10.1534/genetics.107.072926

Adaptive Walks Toward a Moving Optimum

2007· article· en· W2134631886 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueGenetics · 2007
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicEvolution and Genetic Dynamics
Canadian institutionsEmergent BioSolutions (Canada)
FundersNatural Environment Research CouncilSight Research UK
KeywordsBiologyAdaptation (eye)Evolutionary biologyFitness landscapeGeneticsFixation (population genetics)Natural selectionEnvironmental changeFolding (DSP implementation)PhenotypeEvolutionary dynamicsAdaptive evolutionStability (learning theory)Selection (genetic algorithm)EcologyGeneClimate changeDemographyComputer scienceNeuroscience

Abstract

fetched live from OpenAlex

We investigate how the dynamics and outcomes of adaptation by natural selection are affected by environmental stability by simulating adaptive walks in response to an environmental change of fixed magnitude but variable speed. Here we consider monomorphic lineages that adapt by the sequential fixation of beneficial mutations. This is modeled by selecting short RNA sequences for folding stability and secondary structure conservation at increasing temperatures. Using short RNA sequences allows us to describe adaptive outcomes in terms of genotype (sequence) and phenotype (secondary structure) and to follow the dynamics of fitness increase. We find that slower rates of environmental change affect the dynamics of adaptive walks by reducing the fitness effect of fixed beneficial mutations, as well as by increasing the range of time in which the substitutions of largest effect are likely to occur. In addition, adaptation to slower rates of environmental change results in fitter endpoints with fewer possible end phenotypes relative to lineages that adapt to a sudden change. This suggests that care should be taken when experiments using sudden environmental changes are used to make predictions about adaptive responses to gradual change.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.510
Threshold uncertainty score0.679

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.257
Teacher spread0.245 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it