Suicidality in Adolescents and Adults with Fetal Alcohol Spectrum Disorders
Bibliographic record
Abstract
Dear Editor: Suicide is the ninth leading cause of death in the US and the third leading cause for Americans aged 15 to 24 years (1). In Canada, suicide rates are higher (2). Fetal alcohol spectrum disorders (FASD) are common and preventable developmental disabilities with a prevalence of 1 in 100 (3). Previous reports suggest that individuals with FASD are at risk for suicide (4,5). An individual with a typical clinical profile for FASD will evidence several risk factors for suicide (for example, impulsivity, a comorbid mood disorder, and substance abuse problems) and should be monitored closely, irrespective of intellectual ability. We report pilot study data and 2 case studies to illustrate the underappreciated risk of suicide in adolescents and adults with FASD and its clinical manifestation. A pilot study (6) examined 11 adults with FASD (3 men and 8 women, aged 18 to 30 years, with IQs ranging from 72 to 113) drawn from the Fetal Alcohol Syndrome Follow-up Study database of the University of Washington Fetal Alcohol and Drug Unit. It found that approximately one-half the subjects reported at least 1 life-time suicide attempt on the Lifetime Parasuicide/Suicide Attempt Count (LPS, 7). History of mental illness was not a selection criterion, and only one subject was receiving any mental health treatment (medication management only) at the time of the interview. When each subject's most serious self-harm incident was evaluated for intent and lethality (8), 2/11 subjects (18%) had a severe suicide attempt, 3/11 (27%) had a moderate-risk attempt, 1/11 (9%) had a low-risk attempt, and 5/11 (46%) had no lifetime attempts. These rates of lifetime suicide attempts are higher than the general population rate of 4.6% reported in the National Comorbidity Study (9). The following case studies illustrate that the lethality of a suicide attempt or self-harm behaviour often does not correlate with degree of intent in patients with FASD. case Report 1 The first case is that of an adopted Native man, aged 19 years, with full fetal alcohol syndrome, normal intellectual abilities, and a long history of attention-deficit hyperactivity disorder and affective instability. He was enraged with his parents because he felt they were smothering him by setting strict curfews. However, he was unable to express his feelings verbally and instead expressed them through a suicide attempt. Intending to kill himself, he took 8 to 10 methylphenidate tablets (10 mg) and slashed his right shoulder, but he did not understand that he had taken a sublethal dose. In a family session the day after his suicide attempt, he was better able to verbalize his feelings and expressed overwhelming suicidal urges arising from his feeling trapped. …
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.008 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.004 | 0.004 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".