Hemoglobin Wayne in a British Family: Identification by Electrospray Ionization/Mass Spectrometry
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Bibliographic record
Abstract
Hemoglobin (Hb) Wayne (an elongated α-chain frameshift variant that exists as 2 forms, Hb Wayne Asn and Hb Wayne Asp) was first described in 1976 in a Caucasian neonate in Pike County, Central Georgia, whose grandparents originated from Birmingham, Alabama (1). Two other families have been reported, one a Caucasian family from Michigan (2), and the other from Canada (3). Clinically, Hb Wayne leads to an increased oxygen affinity Hb with noncooperativity and a markedly reduced Bohr effect. Hb Wayne Asn and Hb Wayne Asp exhibit differences in their carbon monoxide-binding properties (4). We report the identification of Hb Wayne in a 28-year- old Caucasian diabetic female patient whose blood was undergoing analysis for glyco-Hb. Her initial pathologic investigations showed no abnormalities (144 g/L Hb; erythrocytes, 5.09 × 1012/L; packed cell volume, 0.437 L/L; mean cell volume, 85.8 fL; mean cell Hb, 28.3 pg; mean cell Hb concentration, 330 g/L). Analysis of a hemolysate for glyco-Hb using a HA-8140 analyzer (Menarini Diagnostics Ltd.) revealed a slight shoulder on the glycated Hb peak with …
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it