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Record W2135456872 · doi:10.1038/ng.450

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

2009· article· en· W2135456872 on OpenAlexaff
Rosalind A. Eeles, Zsofia Kote‐Jarai, Ali Amin Al Olama, Graham G. Giles, Michelle Guy, Gianluca Severi, Kenneth Muir, John L. Hopper, Brian E. Henderson, Christopher A. Haiman, Johanna Schleutker, Freddie C. Hamdy, David E. Neal, Jenny Donovan, Janet L. Stanford, Elaine A. Ostrander, Sue A. Ingles, Esther M. John, Stephen N. Thibodeau, Daniel J. Schaid, Jong Y. Park, Amanda B. Spurdle, Judith A. Clements, Joanne L. Dickinson, Christiane Maier, Walther Vogel, Thilo Dörk, Timothy R. Rebbeck, Kathleen A. Cooney, Lisa Cannon‐Albright, Pierre O. Chappuis, Pierre Hutter, Maurice P. Zeegers, Radka Kaneva, Hongwei Zhang, Yong‐Jie Lu, William D. Foulkes, Dallas R. English, Daniel Leongamornlert, Malgorzata Tymrakiewicz, Jonathan J. Morrison, Audrey Ardern‐Jones, Amanda L. Hall, Lynne T. O'Brien, Rosemary Wilkinson, Edward J. Saunders, Elizabeth Page, Emma J Sawyer, Stephen M. Edwards, David P. Dearnaley, Alan Horwich, Robert Huddart, Vincent Khoo, Christopher Parker, Nicholas van As, Christopher Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin S. Cooper, Melissa C. Southey, Artitaya Lophatananon, Jo‐Fen Liu, Laurence N. Kolonel, Loı̈c Le Marchand, Tiina Wahlfors, Teuvo L.J. Tammela, Anssi Auvinen, Sarah J. Lewis, Angela Cox, Liesel M. FitzGerald, Joseph S. Koopmeiners, Danielle M. Karyadi, Erika M. Kwon, Mariana C. Stern, Román Corral, Amit D. Joshi, Ahva Shahabi, Shannon K. McDonnell, Thomas A. Sellers, Julio M. Pow‐Sang, Suzanne K. Chambers, Joanne F. Aitken, Robert A. Gardiner, Jyotsna Batra, Mary Anne Kedda, Felicity Lose, Andrea Polanowski, Briony Patterson, Jürgen Serth, Andreas Meyer, Manuel Luedeke, Klara Stefflova, Anna M. Ray, Ethan M. Lange, Humera Khan, Chavdar Slavov, A. Mitkova, Guangwen Cao, Douglas F. Easton

Bibliographic record

VenueNature Genetics · 2009
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsMcGill University
FundersCancer Research UKNational Institutes of HealthNational Cancer InstituteNational Institute for Health and Care ResearchNational Center for Research ResourcesNational Institute of General Medical Sciences
KeywordsProstate cancerSingle-nucleotide polymorphismGenome-wide association studyBiologyCancerAlleleGeneticsGenetic associationProstateDiseaseCase-control studyOncologyInternal medicineGenotypeGeneMedicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.004
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.002
Science and technology studies0.0010.001
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.300
Teacher spread0.291 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations424
Published2009
Admission routes1
Has abstractno

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