The Effect of Alendronate on Symptoms of Knee Osteoarthritis: A Randomized Controlled Trial
Bibliographic record
Abstract
Background: Knee osteoarthritis is a common degenerativejoint disorder and a major cause of pain and disability. Recentstudies have suggested that bisphosphonates such as alendronatemay have a role in the treatment of osteoarthritis. Thepurpose of the present study was to investigate the potentialeffect of alendronate on the symptoms of knee osteoarthritis.Methods: Thirty nine patients with mild to moderate kneeosteoarthritis were enrolled in a randomized, double-blind,placebo-controlled trial with parallel-group design. The patientsreceived either placebo or alendronate pills (70mg,weekly) in a blinded fashion for six months. Symptoms of osteoarthritiswere scored by Western Ontario and McMasterUniversities (WOMAC) osteoarthritis index at enrollment andat weeks 4, 12, and 24.Results: In both groups there was a significant improvementin total WOMAC score and WOMAC subscales scores ofpain, stiffness, and function at 4, 12, and 24 weeks of treatment.Maximum improvement occurred at week 4. There wasno statistically significant difference between the two groupsregarding their total WOMAC score and its subscales at theend of weeks 4, 12, or 24 (P=0.94).Conclusion: Alendronate does not reduce symptoms of mildto moderate knee osteoarthritis.Trial Registration Number: IRCT138803271479N2
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.004 | 0.002 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.009 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".