Modulation of DNA methylation and phenotypic switching in Smooth Muscle Cells by the extracellular matrix microenvironment
Why this work is in the frame
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Bibliographic record
Abstract
Background Partial bladder outlet obstruction due to neurogenic bladder or mechanical obstruction is common amongst the population and can cause bladder injury and dysfunction. Bladder Smooth Muscle Cells (BSMCs) undergo phenotypic changes such as hyper-proliferation, de-differentiation and altered expression of integrins and ECM proteins.[1] Extracellular matrix changes are often crucial inciting events for fibroproliferative disease.[2] Epigenetic change, specifically DNA methylation, may be important factors underlying the persistent fibroproliferative phenotype. Previously, damaged matrix (heat-denatured collagen, DNC) induced hyper-proliferation of bladder smooth muscle cells (BSMC) and the phenotype was not reverted upon a return to normal matrix. [3] We examined the dependency of matrix-induced fibroproliferation and SMC phenotype on DNA methyltransferase activity. The cooperativity of matrix with other inciting stimuli (growth factors, hypoxia and strain) associated with bladder obstruction was also examined.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it