Nutritional and Physiological Effects of Dietary Sinapic Acid (4-Hydroxy-3,5-Dimethoxy-Cinnamic Acid) in Broiler Chickens and its Metabolism in the Digestive Tract
Bibliographic record
Abstract
Sinapic acid (SA) is a major free phenolic acid in rapeseed meal, with the majority found in the esterified form of sinapine. Two experiments were conducted to delineate the effect of dietary SA on broiler chickens, in terms of performance, toxicity, and nutrient digestibility. In the first experiment, 80 male broiler chicks were randomly assigned to 5 diets adequate in all nutrients and containing 0, 0.05, 0.10, 0.15, or 0.20% dietary SA. Performance from 0 to 18 d of age and the relative size of all the internal organs and intestines were not affected (all P>0.05) by dietary treatment. In addition, dietary SA had no effect (P>0.05) on the serum activity of creatine kinase and lactate dehydrogenase, which indicated that there was no damage to skeletal muscle, heart muscle, liver, kidneys, or brain. The objectives of the second experiment were to investigate the effect of SA on nutrient retention and to study the retention of SA in the digestive tract. Male broiler chicks (96) were randomly assigned into 4 treatments containing dietary SA at 0, 0.025, 0.05, and 0.10%. Dietary SA at the 0.025% level increased feed intake compared with control (P<0.05). Regression analysis indicated a quadratic response for both weight gain and feed intake (P<0.05) as SA increased in the diet. Again, dietary SA did not affect the relative weights of bursa of Fabricius, liver, kidney, or digestive tract. Nitrogen-corrected AME and protein digestibility were not affected by SA level. A negative linear relationship was found between dietary SA level and apparent ileal digestibility of Met, Thr, Ser, Pro, Gly, Ala, and Phe. Sinapic acid disappearance in the ileum was above 97% for all SA levels, whereas apparent SA retention in excreta ranged from 64 to 79%. Sinapic acid at dietary levels investigated in this research is apparently not toxic to broiler chickens but may have a negative effect on amino acid digestibility at higher levels.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".