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Record W2136891290 · doi:10.1111/iwj.12459

Is leg pain a significant contributor to health care budget pain?

2015· review· en· W2136891290 on OpenAlexaboutno aff
Douglas Queen, Mariam Botros, Keith G Harding

Bibliographic record

VenueInternational Wound Journal · 2015
Typereview
Languageen
FieldMedicine
TopicPeripheral Artery Disease Management
Canadian institutionsnot available
Fundersnot available
KeywordsMedicineAmputationAsymptomaticStroke (engine)Blood flowClaudicationDiseaseDiabetes mellitusCardiologyPeripheralQuality of life (healthcare)Vascular diseaseArterial diseaseSurgeryInternal medicine

Abstract

fetched live from OpenAlex

Peripheral arterial disease (PAD) has major impact on leg function, and the most common symptom of PAD is the exertional leg muscle fatigue, cramping or pain known as ‘claudication’. Lack of leg blood flow, thus, is associated with disability and a poor quality of life. When PAD is not promptly diagnosed and treated and leg blood flow is severely decreased, it may lead to ‘critical limb ischaemia’ and amputation. PAD is also a warning sign that other arteries in the body, including those in the heart and brain, may also be blocked. Thus, it is also associated with a high risk of heart attack, stroke and even death. These are significant health care issues and it has been shown that an insufficient arterial blood flow can impede wound healing, making it almost impossible to heal wounds with any treatment. Two out of three patients are not aware of PAD, a common vascular disease that affects as many as 28 000 000 people in the G7 countries alone, 50% of which are asymptomatic. Patients with chronic diabetes or advanced vascular disease can develop pain in their legs as a consequence of the underlying disease. PAD is a term used to describe diseased blood vessels that are not related to the heart. It results from a build-up of plaque in the walls of blood vessels (arteries). This reduces or blocks the flow of blood to the legs and other organs. PAD is most commonly seen in the legs. If untreated this can lead to major amputations and even when treated around 40% of patients will need an amputation. Amputations are expensive both to the health care system and also society, as these patients become less productive members of society. Treatment costs are not insignificant but are certainly less expensive than the costs associated with ongoing leg pain or amputation. Once diagnosed there are three main approaches to treating PAD: lifestyle changes, medication and in some cases endovascular procedures or surgery. A health care provider will determine the best treatment option in partnership with the patient based on his or her symptoms, life circumstances and medical history. PAD prevalence is increasing globally, fuelled by increasing rates of obesity and diabetes. The condition affects around 28 million individuals in the G7 (Table 1), however, at present the majority of PAD patients remain undiagnosed and untreated. PAD is often under-diagnosed because awareness of the disease is low both within the public and the general medical community. The medical products industry and specialist health care societies in many of the G7 countries are heavily invested in health care education and public awareness programmes, as a way to increase disease awareness and to promote earlier detection. Increasing disease prevalence and higher detection rates represent a potentially significant resource, both personnel and financial, burden to the Canadian health care system. If left to progress, PAD adversely impacts patient's quality of life and independence by limiting mobility through pain or amputation. The consequences of amputation can also reduce patient mortality. This lack of independence has serious implication in terms of indirect costs to society. Early detection and cost-effective treatment will be key to managing and reducing this burden. Under-diagnosis is attributed to a limited degree of referring physician awareness about the diagnosis of PAD, as well as a lack of funding for screening programmes. Patient and public awareness of PAD is also low; many patients attribute PAD symptoms to the ageing process and do not seek treatment. Patient awareness programmes run by health care provider societies can provide the public with knowledge of the common symptoms of the disease and how to seek proper diagnosis and treatment. It is time for the wound care community to highlight this growing issue and to take a lead in heightening the awareness.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.654
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.052
GPT teacher head0.396
Teacher spread0.345 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2015
Admission routes1
Has abstractyes

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