P3‐091: Ambulatory blood pressure and cognitive function in nondemented older adults: Findings of the maracaibo aging study
Bibliographic record
Abstract
Little is known about the influence of day/night blood pressure (BP) variations on specific cognitive functions. The goal of this study was to determine the effects of levels and variation in blood pressure, assessed by ambulatory blood pressure monitoring (ABPM), on specific cognitive domains in healthy, non-demented, community dwelling elders. A comprehensive battery of neuropsychological tests was used to evaluate cognitive functions. 400 female and 195 male participants of the Maracaibo Aging Study (MAS) underwent ABPM with Spacelabs 90207 monitors for 24 h. The subjects also underwent neuropsychological, neuropsychiatric, physical assessments, and laboratory tests that included total plasma homocysteine (Hcy), clinical chemistry, and ApoE genotyping. Multiple regression models were used to evaluate relationships between results of cognitive tests and BP parameters. Sitting casual and median 24-h diastolic blood pressure (DBP) but not systolic blood pressure (SBP), were significantly lower in women than men. 75.5% of women and 77.7% of men had high blood pressure (>140/90 mmHg); 43.2% of women and 29% of men had isolated systolic hypertension (>140/10% nocturnal drop in SBP were classified as dippers, which included 23.8% of women and 33.3% of men (p = 0.02). After adjustment for age, education, Hcy, and ApoE-∊4 status, there were significant gender differences in the associations between cognitive functions and blood pressure parameters. In women, scores on BVRT Matching and delayed recall tests had significant negative correlations with 24 h and nocturnal SBP. In men, BVRT Matching scores, but not delayed recall tests, were correlated with nocturnal SBP. Male dippers had higher scores than non-dippers in the tests of similarities, BVRT Matching, and delayed recognition, but female dippers and non-dippers did not exhibit different performances in any of the cognitive variables. Specific cognitive functions were related to median day and night SBP and DBP, assessed by ABPM, but the relationships differed between genders. Reduced nocturnal BP drop was associated with specific cognitive deficits in men. Further studies are required to clarify the mechanisms underlying these findings.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".