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Record W2136945670 · doi:10.1093/alcalc/agh177

CAN ALCOHOL LEAD TO INHIBITION OR DISINHIBITION? APPLYING ALCOHOL MYOPIA TO ANIMAL EXPERIMENTATION

2005· article· en· W2136945670 on OpenAlexafffund
Naomi K. Grant, Tara K. MacDonald

Bibliographic record

VenueAlcohol and Alcoholism · 2005
Typearticle
Languageen
FieldNeuroscience
TopicNeurotransmitter Receptor Influence on Behavior
Canadian institutionsQueen's University
FundersCanadian Institutes of Health Research
KeywordsDisinhibitionImpulsivityAlcoholPsychologyAggressionAnimal modelSalience (neuroscience)Alcohol abuseDevelopmental psychologyClinical psychologyPsychiatryCognitive psychologyMedicine

Abstract

fetched live from OpenAlex

AIMS: Animal experimentation often demonstrates that alcohol leads to disinhibited behaviour, such as increased aggression, increased social behaviour, or increased impulsivity. However, human experimentation demonstrates that alcohol can have either disinhibiting or inhibiting effects on behaviour, depending on salient environmental cues. Our aim was to illustrate how alcohol myopia theory could be applied to the literature assessing the effects of alcohol on behaviour in animals. METHODS: The effects of alcohol on animal behaviour were reviewed in several domains, including aggression, social behaviours, and impulsivity. Suggestions for testing alcohol myopia with animal research paradigms were provided. RESULTS: Current animal research paradigms are often designed in such a way that alcohol myopia cannot be tested. To test alcohol myopia, we recommend manipulating the salience of both impelling and inhibiting environmental cues. CONCLUSIONS: Disinhibition alone cannot explain alcohol's effects on behaviour. We contend that alcohol myopia theory helps to explain some contradictory findings in the human and animal literature. We encourage animal researchers to develop research paradigms to provide tests of alcohol myopia.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.029
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0000.001
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.074
GPT teacher head0.348
Teacher spread0.275 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations14
Published2005
Admission routes2
Has abstractyes

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