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Record W2137186819 · doi:10.1038/ng.424

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2

2009· article· en· W2137186819 on OpenAlexaff
Honglin Song, Susan J. Ramus, Jonathan P. Tyrer, Kelly L. Bolton, Aleksandra Gentry‐Maharaj, Eva Wozniak, Hoda Anton‐Culver, Jenny Chang‐Claude, Daniel W. Cramer, Richard A. DiCioccio, Thilo Dörk, Ellen L. Goode, Marc T. Goodman, Joellen M. Schildkraut, Thomas A. Sellers, Laura Baglietto, Matthias W. Beckmann, Jonathan Beesley, Jan Blaakær, Michael E. Carney, Stephen J. Chanock, Zhihua Chen, Julie M. Cunningham, Ed Dicks, Jennifer A. Doherty, Matthias Dürst, Arif B. Ekici, David Fenstermacher, Brooke L. Fridley, Graham G. Giles, Martin Gore, Immaculata De Vivo, Peter Hillemanns, Claus Høgdall, Estrid Høgdall, Edwin S. Iversen, Ian Jacobs, Anna Jakubowska, Dong Li, Jolanta Lissowska, Jan Lubiński, Galina Lurie, Valerie McGuire, Krzysztof Mędrek, Patricia G. Moorman, Kirsten B. Moysich, Steven A. Narod, Catherine Phelan, Carole Pye, Harvey A. Risch, Ingo B. Runnebaum, Gianluca Severi, Melissa C. Southey, Daniel O. Stram, Falk C. Thiel, Kathryn L. Terry, Ya-Yu Tsai, Shelley S. Tworoger, David J. Van Den Berg, Robert A. Vierkant, Shan Wang‐Gohrke, Penelope M. Webb, Lynne R. Wilkens, Anna H. Wu, Hannah Yang, Wendy R. Brewster, Argyrios Ziogas, Richard S. Houlston, Ian Tomlinson, Alice S. Whittemore, Mary Anne Rossing, Bruce A.J. Ponder, Celeste Leigh Pearce, Roberta B. Ness, Usha Menon, Susanne K. Kjær, Jacek Gronwald, Montserrat García‐Closas, Peter A. Fasching, Douglas F. Easton, Georgia Chenevix‐Trench, Andrew Berchuck, Paul D.P. Pharoah, Simon A. Gayther

Bibliographic record

VenueNature Genetics · 2009
Typearticle
Languageen
FieldMedicine
TopicOvarian cancer diagnosis and treatment
Canadian institutionsCoalition for Research in Women's HealthLunenfeld-Tanenbaum Research Institute
FundersNational Cancer InstituteNational Institute for Health and Care ResearchCancer Research UKWellcome Trust
KeywordsGenome-wide association studySingle-nucleotide polymorphismOvarian cancerOdds ratioBiologyLocus (genetics)SNPGenetic associationGeneticsOncologyCancerGenotypeInternal medicineMedicineGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.016

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.002
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0050.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.307
Teacher spread0.293 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations311
Published2009
Admission routes1
Has abstractno

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