An Unusual Kindred of the Multiple Endocrine Neoplasia Type 1 (<i>MEN1</i>) in Japanese<sup>1</sup>
Bibliographic record
Abstract
Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant predisposition to hyperplasia/tumor of the parathyroid glands, endocrine pancreas, and anterior pituitary (1). Recently, the MEN1 gene, which had been mapped to chromosomal region 11q13 (2), was identified by positional cloning (3). The MEN1 gene, which is composed of 10 exons, encodes a 610-amino acid protein (menin) (3). Germ line mutations of the MEN1 gene were detected at high frequency in both familial and sporadic cases of MEN 1 in Caucasians (3–8) and in other ethnic groups, including Japanese (9–12). The prevalence of pituitary adenomas in patients with MEN 1 is very variable, ranging from 15–60% (13–15). This wide range of values presumably depends on different methodological approaches. Of the various subtypes of pituitary adenomas, prolactinomas are most commonly seen in association with the MEN 1, followed by GH-secreting adenomas, ACTH-secreting adenomas, and nonfunctioning adenomas (14–16). In several pedigrees, many affected members with pituitary adenomas were found to have only prolactinomas (17–19). There is a distinct phenotype of MEN 1 in which a prolactinoma and hyperparathyroidism are dominant manifestations and a pancreatic endocrine tumor is rare. The phenotype is termed “the prolactinoma variant of MEN 1” (19–21). The prolactinoma variant of MEN 1, referred to as MEN 1Burin, was described in one Newfoundland family (19, 20), one family from Pacific Northwest (18), and one other family (21). Of 83 affected family members of MEN 1Burin, 93% had parathyroid tumors, 37% had prolactinoma, and 2.5% had gastrinoma (21). One of the eight affected individuals in the Pacific Northwest family, 100% had parathyroid tumors, 75% had prolactinoma, and 12% had gastrinoma (21). Genetic analysis of families from MEN 1Burin and Pacific Northwest disclosed that the patients have the germ line mutation of MEN1 gene (4, 20). We describe in this study one Japanese unusual MEN 1 kindred in which the four of five mutation carriers were affected and have developed prolactinoma.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.003 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".