Protective Effect of Melatonin Against Malathion Induced Alterations in Antioxidant Defense System and Morphology of Erythrocytes in Wistar Rats
Bibliographic record
Abstract
Malathion intoxication has been shown to produce oxidative stress due to the generation of free radicals and alter the antioxidant defense system in erythrocytes. Previous studies have shown the ameliorative role melatonin against oxidative stress induced by generation of free radicals. Present study was designed to investigate the protective effect of melatonin against malathion induced oxidative stress. For this purpose, male Wistar rats were randomly divided into four groups: Control; Melatonin (10mg/Kg body weight) group; Malathion (250mg/Kg body weight) treated group; Malathion + Melatonin treated group. Animals were administered an acute dose of malathion orally. The result of this study shows that in vivo administration of malathion caused inhibition in AChE activity in erythrocytes. Malathion intoxication also significantly increased the oxidative damage as evidenced by increased level of LPO and GSH content. The Inhibition of GSH level and increased lipid peroxidation in erythrocytes was relieved in malathion + melatonin group. Enhanced activities of SOD, CAT, GR and GPx were observed in erythrocytes of malathion treated rats as compared to control group. Moreover, melatonin supplementation in malathion treated rats maintain normal level of antioxidant enzymes as compared to malathion treated rats which indicates that melatonin provide protection against malathion-induced oxidative stress in erythrocytes. No significant change in the membrane bound enzymes such as Na+/K+-ATPase, Mg2+-ATPase and Ca2+-ATPase was observed in malathion intoxicated rats. Findings of scanning electron micrographs of erythrocytes revealed that both the malathion treated and malathion+melatonin treated groups exhibited morphological changes in erythrocytes. However, concomitant melatonin supplementation normalized the morphological alterations in erythrocytes induced by malathion toxicity. In conclusion, melatonin supplementation may ameliorate malathion-induced oxidative imbalance by enhancing the glutathione level, reducing lipid peroxidation and normalizing antioxidant enzyme activities in erythrocytes.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".