Classification of primary progressive aphasia and its variants
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No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Abstract
This article provides a classification of primary progressive aphasia (PPA) and its 3 main variants to improve the uniformity of case reporting and the reliability of research results. Criteria for the 3 variants of PPA--nonfluent/agrammatic, semantic, and logopenic--were developed by an international group of PPA investigators who convened on 3 occasions to operationalize earlier published clinical descriptions for PPA subtypes. Patients are first diagnosed with PPA and are then divided into clinical variants based on specific speech and language features characteristic of each subtype. Classification can then be further specified as "imaging-supported" if the expected pattern of atrophy is found and "with definite pathology" if pathologic or genetic data are available. The working recommendations are presented in lists of features, and suggested assessment tasks are also provided. These recommendations have been widely agreed upon by a large group of experts and should be used to ensure consistency of PPA classification in future studies. Future collaborations will collect prospective data to identify relationships between each of these syndromes and specific biomarkers for a more detailed understanding of clinicopathologic correlations.
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The record
- Venue
- Neurology
- Topic
- Genomics and Rare Diseases
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- —
- Funders
- National Center for Research ResourcesNational Institute on Deafness and Other Communication DisordersNational Institute on AgingAustralian Research CouncilNational Institutes of HealthUniversity of OxfordVlaamse regeringKU LeuvenBristol-Myers SquibbForest LaboratoriesCanadian Institutes of Health ResearchFonds Wetenschappelijk OnderzoekElanEisaiNational Institute of Neurological Disorders and StrokeUniversity of CambridgeNatural Sciences and Engineering Research Council of CanadaBaxter InternationalPfizerHeart and Stroke Foundation of CanadaCanadian Stroke NetworkWellcome TrustGlaxoSmithKlineAlzheimer SocietyH. Lundbeck A/SMyriad GeneticsEli Lilly and CompanySanofiAlzheimer's AssociationU.S. Department of Veterans Affairs
- Keywords
- Primary progressive aphasiaConsistency (knowledge bases)OperationalizationNatural language processingComputer scienceReliability (semiconductor)AphasiaMedicinePsychologyArtificial intelligencePathologyFrontotemporal dementiaCognitive psychologyDiseaseDementia
- Has abstract in OpenAlex
- yes