Association of Interleukin 1α Promoter Polymorphism (–889C/T) with Susceptibility to Systemic Sclerosis
Bibliographic record
Abstract
To the Editor: We read with great interest 2 articles1,2 about the association of interleukin 1α (IL-1α) –889C/T promoter polymorphism with systemic sclerosis (SSc). Hutyrová, et al 1 suggested that overexpression of IL-1α-889 T allele carriers among patients with SSc in a Slovak population was significantly associated with risk of SSc. Mattuzzi, et al 2 showed that IL-1α-889C/T was not significantly associated with SSc susceptibility in whites. In fact, IL-1 plays a critical role in connective tissue remodeling, which modulates both degradation and synthesis of extracellular matrix, and has been implicated in the fibrogenic phenotypes … Address correspondence to Dr. J. Wang; E-mail: jwang2006{at}126.com
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.007 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.008 | 0.007 |
| Insufficient payload (model declined to judge) | 0.005 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".