Independent regulation of prostaglandins and monocyte chemoattractant protein-1 by interleukin-1β and hCG in human endometrial cells
Bibliographic record
Abstract
BACKGROUND: Inflammatory mediators such as prostaglandins (PG), chemokines, cytokines and their interactions regulate reproductive functions. The relationship between PG and monocyte chemoattractant protein-1 (MCP-1) has not been elucidated in human endometrium. The presence of hCG receptors in the human endometrium suggests that this embryonic signal may exert a local function in this tissue. Our objectives were to investigate the possible association between PG and MCP-1 and to examine the role of hCG in interleukin-1beta (IL-1beta)-regulated PG and MCP-1 production in human endometrium. METHODS: Primary cell cultures isolated from endometrial biopsies were used as an in vitro model. PG and MCP-1 levels were measured in the culture medium. RESULTS: IL-1beta stimulates the production of both PG and MCP-1. Neither COX inhibitors nor direct addition of PG affects MCP-1 production. By contrast, MCP-1 is able to induce PGE2 and PGF2alpha in a concentration-dependent manner but it does not appear to contribute to the increase in PG accumulation following IL-1beta stimulation. hCG inhibits IL-1beta-induced PG level. However, hCG has no effect on either basal or IL-1beta-mediated MCP-1 level. CONCLUSIONS: PG are not involved in the regulation of MCP-1 production in endometrial cells. hCG appears to play a local function in the endometrium.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".