Trimethoprim–Sulfamethoxazole for Treatment of Stenotrophomonas maltophilia Pneumonia in a Neonate
Bibliographic record
Abstract
Neonates are susceptible to numerous infections. Factors that predispose these patients to nosocomial infections include very low birth weight, small size for gestational age, immunologic immaturity, and exposure to invasive procedures, including insertion of intravascular catheters and assisted ventilation. Stenotrophomonas maltophilia is an opportunistic, gram-negative aerobic bacillus with a high level of intrinsic resistance that is known to cause nosocomial infections. This organism may cause infections of many different systems, including bloodstream infections, urinary tract infections, meningitis, and (most commonly) pneumonia. Since neonatal patients are immunocompromised, infections with S. maltophilia are considered life-threatening in this population. There is very little evidence in the literature indicating the appropriate doses of trimethoprim–sulfamethoxazole required to treat S. maltophilia infections in neonates. This article describes a case in which trimethoprim–sulfamethoxazole was used to treat such an infection, with escalating doses used and tolerated.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".