Mycophenolate mofetil as an immunomodulatory silver bullet in atherogenesis?
Bibliographic record
Abstract
Atherosclerotic vascular disease is a chronic disorder of the vasculature with a substantial impact on society. Although the availability of statins has represented an unparalleled improvement in the treatment of patients with such cardiovascular disease, even more effective measures are required to reverse this disorder with a continuously growing incidence. The classification of atherosclerosis as an inflammatory disorder has prompted the hypothesis that immunomodulation could comprise a novel anti-atherosclerotic strategy. Mycophenolate mofetil (MMF) has various anti-atherogenic effects on major components of the atherosclerotic plaque such as T-lymphocytes, monocytes/macrophages and the endothelium. MMF can inhibit leukocyte recruitment to the subendothelium and the subsequent reduced activation of leukocytes will translate into attenuation of subendothelial crosstalk between T-cells and macrophages. This cascade of events will interrupt the self-perpetuating pro-inflammatory environment within the arterial wall, the hallmark of atherosclerotic vascular disease.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".