Tacrolimus for the treatment of rheumatoid arthritis: are broad-based immunosuppressants still valid?
Bibliographic record
Abstract
Tacrolimus is an immunosuppressive drug that is approved and currently used primarily for the prophylaxis of liver, heart and kidney allograft rejection. Recently, oral tacrolimus 1.5–3 mg/day has been approved in Japan and Canada for the treatment of rheumatoid arthritis in patients who respond insufficiently to other therapies. Tacrolimus potently inhibits calcineurin and, consequently, T-cell activation and proliferation with a mechanism similar to that of cyclosporine. Clinical studies of the efficacy and safety of tacrolimus as monotherapy and in combination with methotrexate have shown it to be less effective than many of the biologics, but similar to cyclosporine for symptomatic relief. Unlike the biologics and other immunosuppressants, it has not been shown to retard progression of joint damage on x-ray. However, clinical response, when it does occur, can be robust and appears to be maintained for at least 18 months. Longer-term safety and efficacy in rheumatoid arthritis have not been studied. In...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.007 | 0.008 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.003 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.004 | 0.004 |
| Insufficient payload (model declined to judge) | 0.008 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".