Myosin motor mediated contraction is enough to produce cytokinesis in the absence of polymerisation
Bibliographic record
Abstract
Actin filament networks play an active role in cytokinesis of eukaryotic cells. These networks, linked mainly by myosin, are concentrated below the cell membrane forming a spherical supporting shell. During cytokinesis, this network is modified such that a contractile ring is formed along the diameter of the shell. We present a realistic three-dimensional simulation model to study the dynamics of this spherical shell of elastic actin filaments and myosin motors. The results show compelling evidence that this fibre-spring model, with the motors activated in a narrow region around the division plane, is sufficient to reproduce most of the essential mechanics of cytokinesis: A spontaneous formation of a contractile ring, a characteristic filament orientation structure, and realistic cleavage furrow dynamics. These results demonstrate that, though cytokinesis is a highly complex process with large variation in intricate details, the fundamental dynamics are largely generic. In particular, motor mediated contraction of an unstructured filament mesh is sufficient to undergo division without concentrated and directed polymerization in the cleavage zone.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".