Synapse Formation and Plasticity: The Roles of Local Protein Synthesis
Bibliographic record
Abstract
From simple reflexes in lower animals to complex motor patterns and learning and memory in higher animals, all nervous system functions hinge upon fundamental, albeit specialized, neuronal units termed synapses. The term synapse denotes the structural and functional building block upon which pivots the enormous information-processing capabilities of our brain. It is the neuronal communications through synapses that ultimately determine who we are and how we react and adapt to our ever-changing environment. Synapses are not only the epic center of our intellect, but they also control myriad traits of our personality, ranging from sinfulness to sainthood (see, e.g., Hamer 2004). Simply put-we are what our synapses deem us to be (LeDoux 2003)! Notwithstanding the reasoning that some aspects of the synaptic arrangement may be genetically hardwired, an overwhelming body of knowledge does nevertheless provide ample plausible evidence that synapses are highly plastic entities undergoing rapid adaptive changes throughout life. It is this adaptability that endows our brain with its "uncanny" powers.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".